HYDROHEAL

Shaping the Future of Bone Healing

From cutting-edge laboratory breakthroughs to real-world patient stories, explore how HYDROHEAL's innovative hydrogel technology is redefining treatment for complex fractures. Stay informed on our latest research, clinical trials, and insights from the world of regenerative medicine.

  • Minimally Invasive
  • Smart Delivery
  • A Sustainable Innovation

Jobs@HYDROHEAL

October 2025

Two partners of the HYDROHEAL consortium are recruiting Postdoctoral Researchers (PDRAs) to join our EU-funded project on advanced hydrogels for bone regeneration.

We invite motivated researchers to contribute to the development of next-generation biomaterials for regenerative medicine.

Tags: Jobs


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Hydroheal @ ESB2025

September 2025

HYDROHEAL consortium members attended the ESB25, the 34th Annual Conference of the Eureopean Society for Biomaterials in Turin, Italy (7-11 Sept. 2025) - focused on fast development of new sources for multifunctional materials, and groundbreaking technologies that enable new structures and devices that improve healthcare, prevent pathologies, and allow patient-oriented therapies; for more details see here.

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Several Members of the project (POLITO, UNEW, UPV, UPC and VET) attended the conferenced, communicated about the project and their contribution to it and connected with the biomaterials community.

Contact us for further question using the contact sheet.

Tags: Conference


PRESS RELEASE

June 2025

A European project to improve the treatment of bone fractures with advanced biomaterials
  • HYDROHEAL will develop new biomaterials for the treatment of vertebral and alveolar (jaw) bone fractures
  • These materials will help reduce the risks of infection and implant rejection, also reducing fracture recovery times

An international consortium led by the Technical University of Valencia (UPV) has launched HYDROHEAL, a European project whose objective is to transform the treatment of bone fractures, using new advanced and smart biomaterials. These materials will help reduce the risks of infection and implant rejection, also reducing fracture recovery times.1

The project, funded by the European Commission with nearly €6.5 million, began this June and will last four years.

Vertebral and jaw fractures

The project focuses on the development and application of new biomaterials in the treatment of vertebral and alveolar fractures (in the jaw, at the base of the teeth), especially in complex cases resulting from osteoporosis, cancer, or trauma.

"The main challenges we face are the formulation and manufacturing of materials, which include a complex variety of components and molecules that must maintain their properties and be released at the right time" notes Dr Piergiorgio Gentile, Distinguished Researcher at UPV and the project coordinator. Microparticles within a hydrogel to regenerate bone

The HYDROHEAL project team aims to develop microparticles that will allow the incorporation and transport of several active pharmaceutical ingredients, encapsulated within bioresorbable and self-solidifying hydrogels. Their use would contribute to improving treatment efficacy, preventing bacterial infections, and speeding up recovery times.

“These materials would not only act as a temporary support for bone regeneration but would also allow for the controlled and targeted release of active ingredients to improve treatment efficacy, significantly reducing the risk of infection and implant rejection. Thanks to HYDROHEAL, we will be able to offer personalized and less invasive solutions that facilitate faster and safer recovery,” emphasizes Dr Gentile.

Innovative Technology

The innovative microparticles will be developed in HYDROHEAL with a fine-tuned “layer-by-layer” coating technology. This method, according to the project consortium, allows for the addition of several layers that carry different active molecules each, facilitating their release and at the right time during treatment.

In addition, HYDROHEAL will integrate artificial intelligence and hybrid digital modelling tools to optimize the design and performance of these materials. “After an initial formulation phase, we will conduct in vitro and in vivo trials to validate efficacy and safety, before moving toward larger-scale sustainable production,” adds Gentile.

A multidisciplinary and European consortium

HYDROHEAL involves 13 partners from 8 European countries, including leading universities, hospitals, technology centres, and companies in the pharmaceutical and biomedical fields.

Coordinated by the Technical University of Valencia (Spain), HYDROHEAL also includes: Newcastle University (United Kingdom), Politecnico di Torino (Italy), Royal College of Surgeons in Ireland (Ireland), Universitat Politècnica de Catalunya (Spain), University of Warwick (United Kingdom), Centre for Process Innovation – CPI (United Kingdom), SITEC Pharmabio (Spain), Separeco (Italy), Vet Ex Machina LTD (Cyprus), Fluidinova S.A. (Portugal), Asphalion S.A. (Spain) and ConsulTech GmbH (Germany).

Contact us for further question using the contact sheet.

Tags: Press release